Staging in colorectal cancer (CRC) is critical to determining the extent of disease, guiding treatment decisions, and establishing prognosis. Once a diagnosis is confirmed, a structured evaluation must be performed to assess local and distant spread before deciding on further management. This comprehensive guide integrates all essential components of CRC staging used in clinical practice. […]
Initial Investigations for Diagnosing Colorectal Cancer (CRC)
The process of diagnosing colorectal cancer (CRC) involves a combination of histopathologic analysis, endoscopic evaluation, radiologic imaging, and selective laboratory testing. Accurate and timely identification is essential for optimal treatment and improved patient outcomes. This article provides a detailed overview of the initial investigations used to diagnose CRC, incorporating all key diagnostic components. Histological […]
The Prognostic Impact of Symptoms in Colorectal Cancer
Colorectal cancer (CRC) remains one of the most common malignancies worldwide, and early detection plays a pivotal role in determining patient outcomes. One often overlooked but critical aspect of diagnosis is the presence and type of symptoms a patient exhibits at the time of detection. Multiple studies have explored how symptomatic presentation correlates with disease […]
Clinical Presentation of Colorectal Cancer (CRC)
Colorectal cancer (CRC) may present in a variety of ways, ranging from incidental findings during routine screening to emergency situations requiring immediate medical intervention. Understanding the spectrum of clinical presentations is critical for timely diagnosis and management. 1. Asymptomatic Presentation A significant proportion of CRC cases are diagnosed in asymptomatic individuals undergoing routine screening […]
Risk Factors of Endometrial Cancer (Uterus Cancer)
Post menopausal hormonal replacement therapy Estero gen alone increases the risk whereas if it is combined with progesterone then there is hardly any risk so it should ideally be taken in combined firm. Obesity Fat in the body is the source of excess of esterogen especially in post menopausal females. This excess estero gen increases […]
Integration of Molecular Subtypes in Endometrial Carcinoma (Uterus Cancer)
Clinical Significance The integration of molecular classification into clinical practice has become pivotal for the risk stratification of endometrial carcinoma (EC). Key guidelines and systems, such as those from the World Health Organization (WHO), European Society of Gynaecological Oncology (ESGO), and others, now emphasize the relevance of molecular subtypes in managing EC. This approach offers […]
How to Prevent Endometrial Cancer (Uterus Cancer)
1. Use of Hormonal contraceptives Estrogen alone increases the risk of endometrial cancer because of its proliferative effect but combination with progestin decreases the risk of endometrial cancer by 30 to 40% and progestin only pill has much more protective effect. This protective effect persists for many years. 2. More the number of pregnancies more […]
Histologic Types of Endometrial Carcinoma (Uterus Cancer)
The World Health Organization (WHO) classifies endometrial carcinoma (EC) into several histological subtypes, each with distinct characteristics and implications for diagnosis and treatment. 1. Endometrioid Carcinoma Prevalence: Endometrioid carcinoma is the most common form, representing 75-80% of all EC cases. Histopathology: This type features tall columnar cells that line closely packed glands, often without intervening […]
Routine Check-Up Saves Post-Menopausal Woman from Cervical Cancer
Dr. Vishnu Agarwal
The Role of Colonoscopy in Colon Cancer
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, but early detection and intervention can significantly reduce its incidence and improve survival rates. Colonoscopy is a crucial tool in the prevention, early detection, and management of colon cancer. This article explores the role of colonoscopy in combating this potentially deadly disease. Colonoscopy: An […]